Endocrine DisordersNewborn ScreeningRUSP

Congenital Adrenal Hyperplasia

CAH

Classic CAH due to 21-hydroxylase deficiency impairs cortisol synthesis, leading to adrenal insufficiency and, in salt-wasting forms, life-threatening electrolyte crisis. Excess androgen production can cause virilization of females. Newborn screening with confirmatory testing enables glucocorticoid and mineralocorticoid therapy before shock or ambiguous genitalia complications dominate.

Prevalence
1 in 15,000
Inheritance
Autosomal recessive
Screened at Birth
Yes
On RUSP
Yes (Recommended Uniform Screening Panel)

About This Data

This disorder is part of the Cureledger rare disease data corpus. We are building privacy-preserving natural history datasets and advocacy tools for rare disease communities. Data is maintained by clinical advisors and the patient community.