Other Newborn ScreeningNewborn ScreeningRUSP
Severe Combined Immunodeficiency
SCID
SCID encompasses genetic defects that abolish T-cell function, leaving infants vulnerable to severe opportunistic infections in early infancy. Hematopoietic cell transplantation or gene therapy can be curative when performed before overwhelming infection. T-cell receptor excision circle (TREC)-based newborn screening enables presymptomatic diagnosis and urgent immunology referral.
- Prevalence
- Approximately 1 in 58,000
- Inheritance
- Variable (X-linked or autosomal recessive depending on gene)
- Screened at Birth
- Yes
- On RUSP
- Yes (Recommended Uniform Screening Panel)
About This Data
This disorder is part of the Cureledger rare disease data corpus. We are building privacy-preserving natural history datasets and advocacy tools for rare disease communities. Data is maintained by clinical advisors and the patient community.