HemoglobinopathiesNewborn ScreeningRUSP
Sickle Cell Disease
SCD
Sickle cell disease is caused by homozygous or compound heterozygous hemoglobin S-related genotypes that polymerize under deoxygenation, producing hemolysis, vaso-occlusion, and organ damage. Comprehensive care includes penicillin prophylaxis, immunizations, transcranial screening, and hydroxyurea when indicated. Newborn screening identifies infants for family education and specialty follow-up before sepsis or stroke risk peaks.
- Prevalence
- Approximately 1 in 365 in African American births (population-dependent)
- Inheritance
- Autosomal recessive
- Screened at Birth
- Yes
- On RUSP
- Yes (Recommended Uniform Screening Panel)
About This Data
This disorder is part of the Cureledger rare disease data corpus. We are building privacy-preserving natural history datasets and advocacy tools for rare disease communities. Data is maintained by clinical advisors and the patient community.