Fatty Acid Oxidation DisordersNewborn ScreeningRUSP
Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
VLCADD
VLCADD impairs mitochondrial beta-oxidation of long-chain fatty acids and can present with hypoglycemia, cardiomyopathy, or hepatic dysfunction in infancy. Long-term management includes structured feeding, medium-chain triglyceride strategies, and illness emergency plans. Screening identifies patients before metabolic or cardiac decompensation.
- Prevalence
- 1 in 40,000-120,000
- Inheritance
- Autosomal recessive
- Screened at Birth
- Yes
- On RUSP
- Yes (Recommended Uniform Screening Panel)
About This Data
This disorder is part of the Cureledger rare disease data corpus. We are building privacy-preserving natural history datasets and advocacy tools for rare disease communities. Data is maintained by clinical advisors and the patient community.